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Found 15815 articles
Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer.
Combination of chemotherapy and immunotherapy targeting offers a promising new treatment modality against ovarian cancer.
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11/18/15
Maximizing the efficacy of MAPK-targeted treatment in PTENLOF/BRAFMUT melanoma through PI3K and IGF1R inhibition.
Large-scale compound sensitivity profiling revealed that PTEN(LOF) melanoma cell lines were sensitive to PI3Kbeta inhibitors.
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11/19/15
Stability of methylation markers in head and neck squamous cell carcinoma.
Methylation markers measured in biopsy samples are representative of gene methylation in later specimens.
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07/20/15
Role of nicotinic acetylcholine receptors in cell proliferation and tumour invasion in broncho-pulmonary carcinomas.
Use of α7 nAChR antagonists to prevent lung cancer progression should be restricted to poorly differentiated tumors.
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09/10/14
Targeting a Plk1-controlled polarity checkpoint in therapy-resistant glioblastoma-propagating cells.
PLK1 activity controls a polarity checkpoint and compensates for BRAF/MAPK inhibition in CD133+ cells.
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11/18/15
Reduction of apoptosis by proanthocyanidin-induced autophagy in the human gastric cancer cell line MGC-803.
Proanthocyanidins exhibit a significant inhibitory effect on the human gastric cancer cell line MGC-803 proliferation.
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09/10/15
PRC2 epigenetically silences Th1-type chemokines to suppress effector T cell trafficking in colon cancer.
PRC2-mediated epigenetic silencing is not only a crucial oncogenic mechanism, but also a key circuit controlling tumor immunosuppression.
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11/15/15
Dysregulation of CDK inhibitors and p53 in HPV-negative endocervical adenocarcinoma.
Alteration of cyclin-dependent kinase inhibitors and p53 status may contribute to carcinogenesis and the clinical behavior of HPV-negative AC.
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02/13/15
NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer.
Tumor cells protect themselves against glucose deprivation-induced oxidative stress by utilizing NAMPT.
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01/19/15
Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics.
mTOR pathway inhibition could be a potential therapeutic approach for this specific subtype of MIBC.
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11/10/15
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