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Found 15815 articles
NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling.
Nedd4 overexpression also promoted an increase in cell surface localization of IGF-1R.
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04/30/15
MicroRNA-21 expression and its pathogenetic significance in cutaneous melanoma.
miR-21 may exert an oncogenic effect in melanoma by favouring redistribution of PTEN to the nucleus.
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01/06/16
MET Exon 14 Mutations in Non-Small-Cell Lung Cancer Are Associated With Advanced Age and Stage-Dependent MET Genomic Amplification and c-Met Overexpression.
MET exon 14 mutations represent a clinically unique molecular subtype of NSCLC.
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01/06/16
A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.
LC-0296 reduces cell proliferation and promotes apoptosis of HNSCC cells.
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01/02/16
A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1.
Intratumor Tregs are partly responsible for the development of anti-PD1-resistant tumors and PD1(hi) CD8(+) T cells.
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04/22/15
HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1γ in cervical malignancy.
PP1γ levels in HPV-16 positive tumour cells are reduced in an E6/E7 dependent manner.
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05/31/14
Epigenetic Silencing of the Putative Tumor Suppressor Gene GLDC (Glycine Dehydrogenase) in Gastric Carcinoma.
GLDC was silenced in GC cell lines and tissues.
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01/02/16
Increased expression of phosphatidylethanolamine-binding protein 4 (PEBP4) strongly associates with human gliomas grade.
Increased PEBP4 expression was an independent prognostic factor for gliomas.
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08/17/15
HER2 drives Mucin-like 1 to control proliferation in breast cancer cells.
MUCL1 silencing abrogated phospho-focal adhesion kinase (FAK).
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07/09/15
miR-128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF-C upregulation.
Molecular basis for the role of miR-128/VEGF-C in the progression of human BC.
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10/21/14
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