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Found 15815 articles
Open-label randomised phase III trial of vinflunine versus an alkylating agent in patients with heavily pretreated metastatic breast cancer.
Disease control rate significantly higher with vinflunine than AA.
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02/27/18
Hormone receptors status: a strong determinant of the kinetics of brain metastases occurrence compared with HER2 status in breast cancer.
Estrogen-receptors and progesterone-receptors negativity independently associated with BM-free survival.
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11/15/17
Melatonin induces the apoptosis and inhibits the proliferation of human gastric cancer cells via blockade of the AKT/MDM2 pathway.
Melatonin also induced upregulation of Bax.
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08/28/17
Administration of Hypoxia-Activated Prodrug Evofosfamide after Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Colorectal Cancer.
Novel means to target CC-IC fraction by adding a HAP after conventional adjuvant therapy.
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02/19/18
TIPE3 differentially modulates proliferation and migration of human non-small-cell lung cancer cells via distinct subcellular location
Stable overexpression of TIPE3 with C-terminal flag promoted growth and migration of NSCLC cells through activation of AKT and ERK.
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03/06/18
The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells
Differential cell fates between hypoxic and non-hypoxic tumor cells only found in tumor cells isolated from hypoxic TME.
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03/06/18
Temporal and geographic variation in the systemic treatment of advanced prostate cancer
Marked geographic variation in use of each therapeutic drug.
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03/06/18
AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity
Inhibition of AKT1 signaling is phenocopied by blocking the mTORC1 pathway with rapamycin.
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03/05/18
High CD8+ and absence of Foxp3+ T lymphocytes infiltration in gallbladder tumors correlate with prolonged patients survival
Presence of Foxp3+ T cells correlated with decreased patient survival.
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03/02/18
Prevalence of pathogenic BRCA1/2 germline mutations among 802 women with unilateral triple-negative breast cancer without family cancer history
gBRCA mutation risk was predicted to be >10% for women diagnosed below approximately 50 years.
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03/07/18
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