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Found 15815 articles
UBE2N promotes melanoma growth via MEK/FRA1/SOX10 signaling.
Systemic delivery of NSC697923, small molecule inhibitor of UBE2N, significantly decreased melanoma xenograft growth.
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09/12/18
MAVERICC, a randomized, biomarker-stratified, phase 2 study of mFOLFOX6-bevacizumab vs FOLFIRI-bevacizumab as first-line chemotherapy in metastatic colorectal cancer.
High plasma VEGF-A levels (>5.1 pg/mL) observed with shorter PFS.
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09/12/18
Multimodality Therapy for N2 Non-Small Cell Lung Cancer: An Evolving Paradigm.
Both treatment strategies produce equivalent and better than expected outcomes.
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02/20/18
KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma.
KX2-361 binds directly to tubulin and disrupts microtubule architecture in glioma cells.
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05/15/18
Addition of triple negativity of breast cancer as an indicator for germline mutations in predisposing genes increases sensitivity of clinical selection criteria
Data confirm and expand previous studies of high frequency of germline mutations.
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09/26/18
Molecular iodine inhibits the expression of stemness markers on cancer stem-like cells of established cell lines derived from cervical cancer
Antineoplastic effect of I2 accompanied by diminished expression of stemness markers.
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09/26/18
Greater family size is associated with less cancer risk: an ecological analysis of 178 countries
Household size consistently significant predictor of all cancer incidence variables.
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09/26/18
Feasibility of whole body vibration during intensive chemotherapy in patients with hematological malignancies – a randomized controlled pilot study
Feasibility of WBV during intensive/high-dose chemotherapy of hospitalized cancer patients.
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09/25/18
Combination of lutetium-177 labelled anti-L1CAM antibody chCE7 with the clinically relevant protein kinase inhibitor MK1775: a novel combination against human ovarian carcinoma
Significantly higher amounts of DSBs detected in IGROV1 cells after combination.
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09/25/18
A drug screening assay on cancer cells chronically adapted to acidosis
Tool to identify anticancer drugs targeting acid-adapted cancer cells.
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09/25/18
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