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Found 15774 articles
Functional genomics identifies predictive markers and clinically actionable resistance mechanisms to CDK4/6 inhibition in bladder cancer
Members of Receptor-Tyrosine Kinases, PI3K-Akt, Ras/MAPK, JAK/STAT or Wnt signaling pathways identified.
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07/22/19
Increased PHGDH expression promotes aberrant melanin accumulation
Aberrant presence of melanin early in hair follicle cycle following PHGDH expression.
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07/22/19
Analysis of the pathogenic variants of BRCA1 and BRCA2 using next-generation sequencing in women with familial breast cancer: a case–control study
Clinical data should be evaluated before genetic testing.
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07/22/19
Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIP s
VEDT increased c-FLIP ubiquitination and degradation.
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07/22/19
Prostate Magnetic Resonance Imaging, with or Without Magnetic Resonance Imaging-targeted Biopsy, and Systematic Biopsy for Detecting Prostate Cancer: A Cochrane Systematic Review and Meta-analysis.
MRI pathway had most favourable outcome in significant and insignificant prostate cancer detection.
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05/01/19
HDAC6 inhibition synergizes with anti-PD-L1 therapy in ARID1A-inactivated ovarian cancer.
Combined HDAC6 inhibition and immune-checkpoint blockade represents potential treatment strategy for ARID1A-mutated cancers.
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07/09/19
Computer Algorithms Show Potential for Improving Dermatologists' Accuracy to Diagnose Cutaneous Melanoma; Results of ISIC 2017.
Top-ranked computer algorithm had ROC area of 0.87, higher than dermatologists.
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01/14/19
Exposure to ambient air pollution and the incidence of lung cancer and breast cancer in the Ontario Population Health and Environment Cohort (ONPHEC).
Positive associations of lung cancer incidence with particulate matter.
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02/27/19
BRD4 promotes gastric cancer progression and metastasis through acetylation-dependent stabilization of Snail.
Non-canonical post-transcriptional regulatory function of BRD4.
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07/12/19
Monoclonal Antibodies Against Human Papillomavirus E6 and E7 Oncoproteins Inhibit Tumor Growth in Experimental Cervical Cancer.
Anti-HPV E6 and E7 mAbs exert inhibition of tumor growth in viral-specific manner.
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01/11/19
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