Expanding spectrum of TK-mutations, bioavailability issues and the emerging problem of primary or secondary TKI-therapy resistance have lead to the search for novel second generation TKIs to improve target potency and to overcome resistant clones. »
03/07/13

Currently available data not sufficient to establish a causal relationship between aluminum exposure and the augmented risk of developing breast cancer. »
03/08/13

Effect of c-Myc gene expression on the proliferative, invasive, and migrative capabilities of hepatocellular carcinoma HepG2 cells. »
03/08/13

High invasion and metastasis are the primary factors causing poor prognosis of patients with hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying these biological behaviors have not been completely elucidated. In this study, we investigate the molecular mechanism by which hypoxia promotes HCC invasion and metastasis through inducing epithelial-mesenchymal transition (EMT). »
03/09/13

Chemotherapy for primary central nervous system lymphoma (PCNSL) is based on methotrexate (MTX), which interferes with both nucleic acid synthesis and methionine metabolism. We have reported previously that genetic variants with influence on methionine metabolism are associated with MTX side effects, that is, the occurrence of white matter lesions as a sign of MTX neurotoxicity. Here, we investigated whether such variants are associated with MTX efficacy in terms of overall survival in MTX-treated PCNSL patients. »
03/10/13

NLRP3 is an important suppressor of NK cell-mediated control of carcinogenesis and metastases. »
03/10/13

Worsening HbA1c control occurred despite ADT being associated with an increased hazard of addition of diabetes medication. »
03/10/13

Changes in dosage or dosage intervals of LHRH agonist therapy in those with a greater or high BMI is not warranted. »
03/10/13

New and promising avenue to diagnose GC and distinguish it from other gastric diseases. »
03/07/13

Inactivation of MYO5B expression in gastric cancer cells expressing endogenous MYO5B inhibits HGF-stimulated MET degradation. »
03/09/13