Role of SIRT1 in response to smoke and a potential role in repressing lung cancer. »
03/12/12

CXCL12/CXCR4 axis has been increasingly identified as an important target in cancer growth. »
03/08/13

PHB protects against colitis-associated cancer by modulating p53- and STAT3-mediated apoptosis. »
03/06/13

Lower DEFB4 copy number associated with susceptibility to cervical cancer. »
03/07/13

Compound K, a major ginsenoside metabolite, inhibited the growth of the clinically relevant pediatric AML cell lines. »
03/12/13

We sought to identify high-risk areas of pancreatic cancer incidence, and determine if clusters of persons diagnosed with pancreatic cancer were more likely to be located near arsenic-contaminated drinking water wells. »
03/12/13

Experimental data suggest that mitochondria is involved in tumorigenesis. However, little is known about the qualitative and quantitative changes of mtDNA in colorectal cancer tissues. We therefore conducted possible correlations of the mitochondrial DNA (mtDNA) copy number in colorectal cancer (CRC) with clinical and pathological findings and CRC prognosis. »
03/12/13

High prion protein (PrP) levels are associated with breast, colon and gastric cancer resistance to treatment and with a poor prognosis for the patients. However, little is known about the underlying molecular mechanism(s) regulating human PrP gene (PRNP) expression in cancers. Because endoplasmic reticulum (ER) stress is associated with solid tumors, we investigated a possible regulation of PRNP gene expression by ER stress. »
03/12/13

In order to analyze postoperative liver regeneration following hepatic resection after chemotherapy, we retrospectively investigated the differences in liver regeneration by comparing changes of residual liver volume in three groups: a living liver donor group and two groups of patients with colorectal liver metastases who did and did not undergo preoperative chemotherapy. »
03/13/13

Metabolic Syndrome (MS) has been correlated to breast carcinogenesis. MS is common in the general population (34%) and increases with age and body mass index. Although the link between obesity, MS and hormone related cancers incidence is now widely recognized, the molecular mechanisms at the basis of such increase are still poorly characterized. Crucial role is supposed to be played by the altered insulin signalling, occurring in obese patients, which fuels cancer cell growth, proliferation and survival. Therefore we focused specifically on insulin resistance to investigate clinically the potential role of insulin in breast carcinogenesis. »
03/14/13