SNPs provide further support for the link between allergies and risk of glioma. »
10/12/12

Results do not support further development of sorafenib in combination with mFOLFOX6 in molecularly-unselected patients with mCRC. »
03/28/13

Among women with lung cancer, prediagnosis intake of soy food is associated with better overall survival. »
03/27/13

CT BCMs, as indicators of nutritional status, are independent predictors of longer hospital stay and poor OS in patients with OC. »
01/29/13

hERG1 as a novel candidate biomarker for aggressive melanoma. »
03/26/13

Advanced or metastatic renal cell carcinoma (RCC) has a poor prognosis, because it is relatively resistant to conventional chemotherapy or radiotherapy. Treatments with human interferon-alpha2b alone or in combination with mammalian target of rapamycin (mTOR) inhibitors have led to only a modest improvement in clinical outcome. One observation made with mTOR inhibitors is that carcinomas can overcome these inhibitory effects by activating the insulin-like growth factor-I (IGF-I) signaling pathway. Clinically, there is an association of IGF-I receptor (IGF-IR) expression in RCC and poor long-term patient survival. We have developed a humanized anti-IGF-IR monoclonal antibody, hR1, which binds to RCC, resulting in effective down-regulation of IGF-IR and moderate inhibition of cell proliferation in vitro. In this work, we evaluate the anti-tumor activity of two novel IGF-1R-targeting agents against renal cell carcinoma given alone or in combination with an mTOR inhibitor. »
04/01/13

We explore the clinical and prognostic significance of expression of vascular endothelial growth factor receptor (VEGFR)-2, platelet-derived growth factor receptor (PDGFR)-beta, and c-Met in patients with hepatocellular carcinoma (HCC). »
04/03/13

Chemotherapeutic treatment of hepatocellular carcinoma often leads to chemoresistance during therapy or upon relapse of tumors. For the development of better treatments a better understanding of biochemical changes in the resistant tumors is needed. In this study, we focus on the characterization of in vivo chemoresistant human hepatocellular carcinoma HUH-REISO established from a metronomically cyclophosphamide (CPA) treated HUH7 xenograft model. »
04/02/13

benefits of potential progesterone therapy for NSCLC patients. »
03/26/13

SOX7 is a transcription factor belonging to the SOX family. Its role in lung cancer is unknown. »
04/04/13