Morusin has the potential to target and kill CSCs, and can inhibit human cervical growth. »
03/28/13

Essential role of deregulated snoRNA biogenesis in tumors. »
04/01/13

New mechanism by which EZH2 functions in breast cancer, and provide direct evidence that EZH2 inhibition reduces breast cancer metastasis in vivo. »
02/08/13

The biomarker identification of human esophageal cancer is critical for its early diagnosis and therapeutic approaches that will significantly improve patient survival. Specially, those that involves in progression of disease would be helpful to mechanism research. »
04/04/13

The Vav family of Rho/Rac guanosine nucleotide exchange factors comprises three members in mammalian cells. Vav3 enhances androgen receptor (AR) activity during progression to androgen independence in prostate cancer. We examined Vav3 small interfering RNA (siRNA) effects on cell proliferation and apoptosis in docetaxel-treated LNCaP cells under chronic hypoxia (LNCaPH). »
04/08/13

The majority of postmenopausal breast cancers are estrogen-dependent. Tumor-derived factors such as prostaglandin E2 (PGE2) stimulate CREB1 binding to cAMP response elements (CREs) on aromatase promoter II (PII), leading to the increased expression of aromatase and biosynthesis of estrogens within human breast adipose stromal cells (ASCs). Hypoxia inducible factor-1alpha (HIF-1alpha), a key mediator of cellular adaptation to low oxygen levels, is emerging as a novel prognostic marker in breast cancer. We have identified the presence of a consensus HIF-1alpha binding motif overlapping with the proximal CRE of aromatase PII. However, the regulation of aromatase expression by HIF-1alpha in breast cancer has not been characterized. This study aimed to characterize the role of HIF-1alpha in the activation of aromatase PII. »
04/08/13

CRIP1 (cysteine-rich intestinal protein 1) has been found in several tumor types, its prognostic impact and its role in cellular processes, particularly in breast cancer, are still unclear. »
04/09/13

The generation and characterization of primary ovarian cancer cells derived from ascites fluids of patients with epithelial ovarian cancer. »
04/10/13

Predictive cancer biomarkers to guide the right treatment to the right patient at the right time are strongly needed. The purpose of the present study was to validate prior results that TIMP-1 alone or in combination with either HER2 or TOP2A copy number, can be used to predict benefit from epirubicin (E) containing chemotherapy compared with cyclophosphamide, methotrexate and fluorouracil (CMF) treatment. »
04/09/13

Possible correlation between inflammation, OSCC development and the influence of HPV infection. »
04/09/13