Immune suppression by MDSC can be initiated in the tumor microenvironment of human melanoma. »
05/02/13

Gains of chromosomes are a poor prognostic marker in ovarian adenocarcinomas. »
08/09/12

Metformin can be a clinically useful adjunct to radiotherapy in NSCLC. »
04/30/13

The objective of this study was to investigate the influence of digestive gastrointestinal absorption function on the pharmacokinetics of the orally-administered anticancer drug, Tegafur-gimestat-otastat potassium (TS-1), by measuring the plasma 5-fluorouracil (5-FU) concentration using stable isotope breath tests. »
12/11/12

PI3K pathway mutation is prominent in proximal colon cancers. »
05/02/13

Early chemotherapy-induced circadian disruption could allow the optimization of rapid chronotherapy and concomitant improvements in safety and efficacy for CRC. »
12/21/12

Structural analogue of curcumin induced molecular changes that underly cell growth arrest and apoptosis in melanoma cells. »
05/04/13

We investigated patterns of failure in patients with locally advanced rectal cancer (LARC) according to chemoradiotherapy (CRT) timing: pre-operative versus post-operative. Also, patterns of failure, particularly distant metastasis (DM), were analyzed according to tumor location within the rectum. »
05/06/13

The Odontogenic Ameloblast-associated Protein (ODAM) is expressed in a wide range of normal epithelial, and neoplastic tissues, and we have posited that ODAM serves as a novel prognostic biomarker for breast cancer and melanoma. Transfection of ODAM into breast cancer cells yields suppression of cellular growth, motility, and in vivo tumorigenicity. Herein we have extended these studies to the effects of ODAM on cultured melanoma cell lines. »
05/07/13

The interplay between genetic susceptibility and carcinogenic exposure is important in the development of haematopoietic malignancies. EPHX1, NQO1 and PON1 are three genes encoding proteins directly involved in the detoxification of potential carcinogens. »
05/07/13