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Found 15790 articles
Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin.
ENT treatment reduced formation of tubulin-based microtentacles.
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08/01/13
Mammalian Target of Rapamycin Complex 2 (mTORC2) Is a Critical Determinant of Bladder Cancer Invasion.
Gene silencing of rictor, a critical component of mTORC2, substantially inhibited bladder cancer cell migration.
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12/13/13
PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma
Genetic alterations that likely lead to PI3K pathway activation identified
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12/17/13
CD98hc (SLC3A2) drives integrin-dependent renal cancer cell behavior
Loss of CD98hc blocks tumorigenic potential in renal cell cancer.
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12/21/13
Podoplanin expression in cancer-associated fibroblasts enhances tumor progression of invasive ductal carcinoma of the pancreas
High ratio of PDPN-expressing CAFs is an independent predictor of poor outcome.
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12/20/13
Progesterone receptor assembly of a transcriptional complex along with activator protein 1, signal transducer and activator of transcription 3 and ErbB-2 governs breast cancer growth and predicts response to endocrine therapy
Progestin induces the assembly of a transcriptional complex among AP-1, Stat3, PR, and ErbB-2.
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12/17/13
Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas
Methylation of Wnt-pathway antagonists represents an additional mechanism of constitutive Wnt-pathway activation.
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12/19/13
Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo
Administration of MK-8776 18 h after gemcitabine caused significantly delayed tumor growth.
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12/21/13
Targeting MET kinase with the small-molecule inhibitor amuvatinib induces cytotoxicity in primary myeloma cells and cell lines
48-hr amuvatinib treatment in high HGF-expressing myeloma cell line, U266, resulted in growth inhibition.
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12/10/13
Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms
Potency of Rott to induce autophagy and apoptosis might be based on its capability to activate several pathways such as AMPK and proteasome inhibition.
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12/23/13
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