Knockdown of PPM1D arrested cell cycle at the G0/G1 phase. »
08/13/14

The small molecule NSC676914A was previously identified as an NF-¿B inhibitor in TPA-stimulated HEK293 cells (Mol Can Ther 8:571-581, 2009). We hypothesized that this effect would also be seen in ovarian cancer cells, and serve as its mechanism of cytotoxicity. OVCAR3 and HEK293 cell lines stably containing a NF-¿B luciferase reporter gene were generated. »
08/12/14

OX26 endowed the PLs with the transport ability across the blood–brain barrier. »
08/13/14

The human dicer1 gene has been predicted to produce several mRNA variants that encode truncated Dicer1 proteins of varying lengths. One of these Dicer1 variants, Dicer1e, was recently found to be differentially expressed in breast cancer cells. Because the expression and function of the Dicer1e protein variant has not been well characterized and the underlying molecular mechanisms for the development of oral squamous cell carcinomas (OSCCs) are poorly understood, the present study sought to characterize the biological role of Dicer1e and determine its relationship, if any, to OSCC pathogenesis. »
08/13/14

Combining taxol with growth factors and aminoacids deprivation leaded to a more than additive reduction of cell viability compared to single treatments. »
04/07/14

Men with morning aMT6s levels below the median had a fourfold statistically significant increased risk. »
05/09/14

RNA interference-mediated knockdown of GREB1 in MASE2 cells decreased their proliferation rate. »
08/08/13

Modified lymph node staging system proposed. »
12/16/13

BRG1 losses in NSCLC cells were associated with variations in chromatin structure, including differences in nucleosome positioning and occupancy. »
08/14/14

As tumors developed, they gradually acquired immunosuppressive features, including accumulation of regulatory T cells (Treg). »
04/15/14