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Found 15815 articles
Overexpression of SMYD2 contributes to malignant outcome in gastric cancer.
SMYD2 has a crucial role in tumor cell proliferation by its overexpression.
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07/21/14
Germline mutation of RPS20, encoding a ribosomal protein, causes predisposition to hereditary nonpolyposis colorectal carcinoma without DNA mismatch repair deficiency.
Mutations in a gene encoding a ribosomal protein can predispose individuals to microsatellite-stable colon cancer.
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04/15/14
NFAT transcriptional activity is associated with metastatic capacity in colon cancer.
8-gene signature comprising genes up-regulated by NFATc1 significantly correlated with worse clinical outcomes in stage II and III.
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10/17/14
Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells.
TMZ-induced DNA damage is linked through PKM2 to changes in pyruvate metabolism.
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10/17/14
Promoter hypermethylation of KLF4 inactivates its tumor suppressor function in cervical carcinogenesis.
Expression of KLF4 in the cervical cancer cell lines at both mRNA and protein levels was drastically increased.
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10/15/14
Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours.
Wit blocks EGF- and IL-6-stimulated binding of STAT3 and STAT5 to EGFR.
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04/14/14
Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies.
Cell-surface AnxA2 has an important regulatory role in EGFR-mediated oncogenic processes by keeping EGFR signalling events in an activated state.
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06/26/14
MicroRNA-137 Upregulation Increases Bladder Cancer Cell Proliferation and Invasion by Targeting PAQR3.
Tumor suppressor gene PAQR3 as a potential miR-137 target gene.
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10/16/14
Increased angiogenesis and FGFR protein expression indicate a favourable prognosis in bladder cancer.
FGFR3 mutation status was correlated with VSA measured by FVIII.
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08/20/14
Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E mutant metastatic melanoma.
NK cell-based immunotherapy (by checkpoint blockade or agonists or cytokines) may combine well with BRAFV600E inhibitor therapy.
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10/30/14
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