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Found 15815 articles
Hsa-miR-146a-5p modulates androgen-independent prostate cancer cells apoptosis by targeting ROCK1.
miR-146a inhibited the basal level of ROCK1 expression by targeting its 3'UTR.
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03/22/15
The role of HOXC6 in prostate cancer development.
HOXC6 upregulation was specific to the epithelial component of PCa.
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07/17/15
Expression profile of COL2A1 and the pseudogene SLC6A10P predicts tumor recurrence in high grade serous ovarian cancer.
TTR was significantly delayed for tumors that simultaneously expressed high COL2A1 and low SLC6A10P.
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06/29/15
HER2 gene mutations in non-small cell lung carcinomas: concurrence with Her2 gene amplification and Her2 protein expression and phosphorylation.
HER2 mutations were observed in 3.6% of NSCLCs, particularly in younger patients.
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03/24/14
Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study.
Some support to the hypothesis that moderate alcohol consumption may be associated with a lower risk of papillary and follicular thyroid carcinomas.
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04/20/15
miR-224 overexpression is a strong and independent prognosticator of short-term relapse and poor overall survival in colorectal adenocarcinoma.
miR-224 is significantly upregulated in malignant colorectal tumors.
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10/07/13
The HMGB1 protein sensitizes colon carcinoma cells to cell death triggered by pro-apoptotic agents.
Findings demonstrate a functional link between cytotoxic signaling cascades triggered by HMGB1 and pro-apoptotic agents.
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09/21/14
Small molecule NSC59984 restores p53 pathway signaling and anti-tumor effects against colorectal cancer via p73 activation and degradation of mutant p53.
Specific targeting of mutant p53 may be essential for anti-cancer strategies.
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08/22/15
Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer.
APC mutations (APC-mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear.
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05/21/15
Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells.
Inhibition of PI3K/Akt by LY294002/si-Akt or of mTOR by rapamycin augmented LicA-induced apoptosis and autophagy.
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05/04/15
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